Room 129 / ROCCABIANCA Team : Arnaud Roccabianca, Sébastien Dallais, Sylvain TOSTAIN, Thomas VERRIER, Guillaume LUQUIENS, Charles MEURICHE, Clément DUFRESNE, Lise MARIN.
Intravenous crystalloid administration is ubiquitous in intensive care, yet whether choice of cristalloid affects patient outcomes remains unknown. The most commonly used crystalloid solution is saline chloride, with more than 200 million liters administered each year in the US alone. However, the high chloride content of saline has been hypothesized to contribute to the development of acute kidney injury in at risk patients. Alternative to saline include balanced crystalloids (electrolyte composition close to the plasma), such as Ringer’s solution (which is significantly more expensive than saline chloride). Data suggest that the use of balanced cristalloids in critically ill adults may decrease rates of acute kidney injury, renal replacement therapy and death. However, these data come from observational studies. One prospective (very questionable) randomized trial comparing saline chloride to balanced crystalloid as vascular filling was made which didn’t find any difference in term of acute kidney injury or death between the two groups. The aim of this project, if feasable, is to determine if the choice between saline chloride or balanced crystalloid as solute for vascular filling at the intial phase of sepsis has a real impact in term of kidney function, risk of renal replacement therapy or death.